Key to Effective Parkinson’s Treatment May Lie in Stem Cells, Researchers SayJuly 27, 2018
One of the most promising therapeutic avenues for Parkinson’s disease is the use of stem cells to replace dopamine-producing neurons, the loss of which is a hallmark of the disease.
This is the focus of a special issue on Parkinson’s disease published in the journal Stem Cells and Development available for free download until Aug. 24.
“The understandable excitement generated by recent successful phase 1 clinical trials in the treatment of Parkinson’s disease (PD) is tempered with worldwide concern for the safe translation of stem cell research to an effective treatment for this terrible disease and other neurological conditions,” Graham C. Parker, PhD, editor-in-chief of the journal, said in a press release. “The research in this special issue reflects the responsible advancement of cell therapy for PD.”
The first article, “Autologous Induced Pluripotent Stem Cell-Derived Neurons to Treat Parkinson’s Disease,” written by Jeanne F. Loring, PhD, from the Scripps Research Institute in California, discusses the use of patient-derived induced pluripotent stem cells (iPSCs) to treat Parkinson’s disease, and upcoming clinical trials to test this method. These iPSCs are fully matured cells that researchers are able to reprogram in vitro to revert them back to a stem cell state, where they are able to grow into any type of cell, including dopaminergic neurons.